ChloroquineV1, Main, Exploration, bibRecord, 001767

Plasmodium falciparum drug resistance in Madagascar: facing the spread of unusual pfdhfr and pfmdr-1 haplotypes and the decrease of dihydroartemisinin susceptibility.

Identifieur interne : 001767 ( Main/Exploration ); précédent : 001766; suivant : 001768

Plasmodium falciparum drug resistance in Madagascar: facing the spread of unusual pfdhfr and pfmdr-1 haplotypes and the decrease of dihydroartemisinin susceptibility.

Auteurs : Valérie Andriantsoanirina [Madagascar] ; Arsène Ratsimbasoa [Madagascar] ; Christiane Bouchier [France] ; Martial Jahevitra [Madagascar] ; Stéphane Rabearimanana [Madagascar] ; Rogelin Radrianjafy [Madagascar] ; Voahangy Andrianaranjaka [Madagascar] ; Tantely Randriantsoa [Madagascar] ; Marie Ange Rason [Madagascar] ; Magali Tichit [France] ; Léon Paul Rabarijaona [Madagascar] ; Odile Mercereau-Puijalon [France] ; Rémy Durand [France] ; Didier Ménard [Madagascar]

Source :

Antimicrobial Agents and Chemotherapy [ 0066-4804 ] ; 2009-11.

RBID : Hal:pasteur-00741124

Abstract

The aim of this study was to provide the first comprehensive spatiotemporal picture of Plasmodium falciparum resistance in various geographic areas in Madagascar. Additional data about the antimalarial resistance in the neighboring islands of the Comoros archipelago were also collected. We assessed the prevalence of pfcrt, pfmdr-1, pfdhfr, and pfdhps mutations and the pfmdr-1 gene copy number in 1,596 P. falciparum isolates collected in 26 health centers (20 in Madagascar and 6 in the Comoros Islands) from 2006 to 2008. The in vitro responses to a panel of drugs by 373 of the parasite isolates were determined. The results showed (i) unusual profiles of chloroquine susceptibility in Madagascar, (ii) a rapid rise in the frequency of parasites with both the pfdhfr and the pfdhps mutations, (iii) the alarming emergence of the single pfdhfr 164L genotype, and (iv) the progressive loss of the most susceptible isolates to artemisinin derivatives. In the context of the implementation of the new national policy for the fight against malaria, continued surveillance for the detection of P. falciparum resistance in the future is required.

Url:

https://hal-pasteur.archives-ouvertes.fr/pasteur-00741124

DOI: 10.1128/AAC.00610-09

Affiliations:

France, Madagascar

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000187
to stream Hal, to step Curation: 000187
to stream Hal, to step Checkpoint: 000195
to stream Main, to step Merge: 001771
to stream Main, to step Curation: 001767

Le document en format XML

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<author><name sortKey="Rabearimanana, Stephane" sort="Rabearimanana, Stephane" uniqKey="Rabearimanana S" first="Stéphane" last="Rabearimanana">Stéphane Rabearimanana</name>
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</author>
<author><name sortKey="Radrianjafy, Rogelin" sort="Radrianjafy, Rogelin" uniqKey="Radrianjafy R" first="Rogelin" last="Radrianjafy">Rogelin Radrianjafy</name>
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<country>Madagascar</country>
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</author>
<author><name sortKey="Andrianaranjaka, Voahangy" sort="Andrianaranjaka, Voahangy" uniqKey="Andrianaranjaka V" first="Voahangy" last="Andrianaranjaka">Voahangy Andrianaranjaka</name>
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          <orgName type="acronym">RIIP</orgName>
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<country>Madagascar</country>
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</author>
<author><name sortKey="Randriantsoa, Tantely" sort="Randriantsoa, Tantely" uniqKey="Randriantsoa T" first="Tantely" last="Randriantsoa">Tantely Randriantsoa</name>
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          <desc>            <address>              <addrLine>B.P. 1274 Antananarivo</addrLine>
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<country>Madagascar</country>
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<author><name sortKey="Rason, Marie Ange" sort="Rason, Marie Ange" uniqKey="Rason M" first="Marie Ange" last="Rason">Marie Ange Rason</name>
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          <desc>            <address>              <addrLine>B.P. 1274 Antananarivo</addrLine>
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<country>Madagascar</country>
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</author>
<author><name sortKey="Tichit, Magali" sort="Tichit, Magali" uniqKey="Tichit M" first="Magali" last="Tichit">Magali Tichit</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-175239" status="VALID">          <orgName>Génopole</orgName>
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          <orgName>Institut Pasteur [Paris]</orgName>
          <date type="start">1887-06-04</date>
          <desc>            <address>              <addrLine>25-28, rue du docteur Roux, 75724 Paris cedex 15</addrLine>
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</hal:affiliation>
<country>France</country>
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</author>
<author><name sortKey="Rabarijaona, Leon Paul" sort="Rabarijaona, Leon Paul" uniqKey="Rabarijaona L" first="Léon Paul" last="Rabarijaona">Léon Paul Rabarijaona</name>
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<author><name sortKey="Mercereau Puijalon, Odile" sort="Mercereau Puijalon, Odile" uniqKey="Mercereau Puijalon O" first="Odile" last="Mercereau-Puijalon">Odile Mercereau-Puijalon</name>
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          <orgName>Institut Pasteur [Paris]</orgName>
          <date type="start">1887-06-04</date>
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          <date type="start">1939-10-19</date>
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<country>France</country>
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</author>
<author><name sortKey="Durand, Remy" sort="Durand, Remy" uniqKey="Durand R" first="Rémy" last="Durand">Rémy Durand</name>
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          <desc>            <address>              <addrLine>Hôpital Avicenne, 125 rue de Stalingrad, 93009, Bobigny Cedex</addrLine>
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          </desc>
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<country>France</country>
</affiliation>
</author>
<author><name sortKey="Menard, Didier" sort="Menard, Didier" uniqKey="Menard D" first="Didier" last="Ménard">Didier Ménard</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-55578" status="VALID">          <orgName>Institut Pasteur de Madagascar</orgName>
          <desc>            <address>              <addrLine>B.P. 1274 Antananarivo</addrLine>
              <country key="MG"></country>
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          <orgName type="acronym">RIIP</orgName>
          <desc>            <address>              <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine>
              <country key="FR"></country>
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            <ref type="url">https://research.pasteur.fr/ip-network</ref>
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</hal:affiliation>
<country>Madagascar</country>
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</analytic>
<idno type="DOI">10.1128/AAC.00610-09</idno>
<series><title level="j">Antimicrobial Agents and Chemotherapy</title>
<idno type="ISSN">0066-4804</idno>
<imprint><date type="datePub">2009-11</date>
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<front><div type="abstract" xml:lang="en">              <p>The aim of this study was to provide the first comprehensive spatiotemporal picture of Plasmodium falciparum resistance in various geographic areas in Madagascar. Additional data about the antimalarial resistance in the neighboring islands of the Comoros archipelago were also collected. We assessed the prevalence of pfcrt, pfmdr-1, pfdhfr, and pfdhps mutations and the pfmdr-1 gene copy number in 1,596 P. falciparum isolates collected in 26 health centers (20 in Madagascar and 6 in the Comoros Islands) from 2006 to 2008. The in vitro responses to a panel of drugs by 373 of the parasite isolates were determined. The results showed (i) unusual profiles of chloroquine susceptibility in Madagascar, (ii) a rapid rise in the frequency of parasites with both the pfdhfr and the pfdhps mutations, (iii) the alarming emergence of the single pfdhfr 164L genotype, and (iv) the progressive loss of the most susceptible isolates to artemisinin derivatives. In the context of the implementation of the new national policy for the fight against malaria, continued surveillance for the detection of P. falciparum resistance in the future is required.</p>
            </div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
<li>Madagascar</li>
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</noRegion>
<name sortKey="Andrianaranjaka, Voahangy" sort="Andrianaranjaka, Voahangy" uniqKey="Andrianaranjaka V" first="Voahangy" last="Andrianaranjaka">Voahangy Andrianaranjaka</name>
<name sortKey="Jahevitra, Martial" sort="Jahevitra, Martial" uniqKey="Jahevitra M" first="Martial" last="Jahevitra">Martial Jahevitra</name>
<name sortKey="Menard, Didier" sort="Menard, Didier" uniqKey="Menard D" first="Didier" last="Ménard">Didier Ménard</name>
<name sortKey="Rabarijaona, Leon Paul" sort="Rabarijaona, Leon Paul" uniqKey="Rabarijaona L" first="Léon Paul" last="Rabarijaona">Léon Paul Rabarijaona</name>
<name sortKey="Rabearimanana, Stephane" sort="Rabearimanana, Stephane" uniqKey="Rabearimanana S" first="Stéphane" last="Rabearimanana">Stéphane Rabearimanana</name>
<name sortKey="Radrianjafy, Rogelin" sort="Radrianjafy, Rogelin" uniqKey="Radrianjafy R" first="Rogelin" last="Radrianjafy">Rogelin Radrianjafy</name>
<name sortKey="Randriantsoa, Tantely" sort="Randriantsoa, Tantely" uniqKey="Randriantsoa T" first="Tantely" last="Randriantsoa">Tantely Randriantsoa</name>
<name sortKey="Rason, Marie Ange" sort="Rason, Marie Ange" uniqKey="Rason M" first="Marie Ange" last="Rason">Marie Ange Rason</name>
<name sortKey="Ratsimbasoa, Arsene" sort="Ratsimbasoa, Arsene" uniqKey="Ratsimbasoa A" first="Arsène" last="Ratsimbasoa">Arsène Ratsimbasoa</name>
</country>
<country name="France"><noRegion><name sortKey="Bouchier, Christiane" sort="Bouchier, Christiane" uniqKey="Bouchier C" first="Christiane" last="Bouchier">Christiane Bouchier</name>
</noRegion>
<name sortKey="Durand, Remy" sort="Durand, Remy" uniqKey="Durand R" first="Rémy" last="Durand">Rémy Durand</name>
<name sortKey="Mercereau Puijalon, Odile" sort="Mercereau Puijalon, Odile" uniqKey="Mercereau Puijalon O" first="Odile" last="Mercereau-Puijalon">Odile Mercereau-Puijalon</name>
<name sortKey="Tichit, Magali" sort="Tichit, Magali" uniqKey="Tichit M" first="Magali" last="Tichit">Magali Tichit</name>
</country>
</tree>
</affiliations>
</record>

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Plasmodium falciparum drug resistance in Madagascar: facing the spread of unusual pfdhfr and pfmdr-1 haplotypes and the decrease of dihydroartemisinin susceptibility.

Plasmodium falciparum drug resistance in Madagascar: facing the spread of unusual pfdhfr and pfmdr-1 haplotypes and the decrease of dihydroartemisinin susceptibility.

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